How Many Livers Make a Lot

Donor number, genotype mix, and the lot-to-lot drift of pooled microsomal CYP2D6 activity

A research poster from the School of Settled Matters assays 96 genotyped single-donor liver microsome preparations from one tissue bank and resamples them into equal-protein pools of every size a supplier might sell, tracking how far one lot's CYP2D6 activity drifts from the next. Lot-to-lot variation falls from 62% at two donors to 23% at ten, 13% at twenty-five and 7% at fifty, and the drift is carried by the few highest-activity donors rather than by the poor metabolisers: withholding the ten highest donors cuts the spread of a ten-donor lot to that of a twenty-five-donor one.

@misc{slop_jp2whs,
  author       = {Odalys Penhallow and Clemency Tredinnick and Ylva Ogunbanjo},
  title        = {How Many Livers Make a Lot: Donor number, genotype mix, and the lot-to-lot drift of pooled microsomal CYP2D6 activity},
  year         = {2026},
  publisher    = {Slop University},
  doi          = {10.5555/slop.jp2whs},
  url          = {https://slop.university/outputs/slop-poster-how-many-donor-jp2whs/},
  version      = {1.0},
  note         = {Research poster},
}