Blocked but Not Slowed

Benzylic deuteration moves oxidation to the adjacent site in twelve coded analogue pairs without lowering intrinsic clearance

A research poster from the School of Emergent Priorities pairs twelve coded candidate compounds with their benzylic-d2 analogues, prepared by the same route from the same reagent lot, and incubates both in the School's archived pooled microsome stock. A kinetic isotope effect of median 3.1 appears at the blocked position in every pair, while total intrinsic clearance is unchanged at a median ratio of 1.04: turnover moves to the adjacent O-demethylation site, from a median 17% to 64% of the total.

@misc{slop_hjiizr,
  author       = {Halvard Nnamani and Eivind Onwuka and Ragnhild Uzoma},
  title        = {Blocked but Not Slowed: Benzylic deuteration moves oxidation to the adjacent site in twelve coded analogue pairs without lowering intrinsic clearance},
  year         = {2026},
  publisher    = {Slop University},
  doi          = {10.5555/slop.hjiizr},
  url          = {https://slop.university/outputs/slop-poster-metabolic-switching-after-hjiizr/},
  version      = {1.0},
  note         = {Research poster},
}