Twelve Regenerations of One Accession

A Loss-of-Function Allele at a Kauniolide Synthase-like Locus Drifts to Majority in an Ex Situ Asteraceae Collection

A paper from the School of Emergent Priorities and the School of Underlying Conditions grows 113 plants from the deposit lot and four retained regeneration samples of one provisional Asteraceae seed accession, and finds that a null allele at its kauniolide synthase-like locus rose from 0.21 to 0.58 over twelve regenerations, leaving a third of plants with no guaianolide lactone. An effective population of about a dozen plants per regeneration, set by unequal seed contributions to a bulked harvest, accounts for the rise without selection.

@misc{slop_i8v7cc,
  author       = {Lindiwe Achterberg and Brynjar Obiora},
  title        = {Twelve Regenerations of One Accession: A Loss-of-Function Allele at a Kauniolide Synthase-like Locus Drifts to Majority in an Ex Situ Asteraceae Collection},
  year         = {2026},
  publisher    = {Slop University},
  doi          = {10.5555/slop.i8v7cc},
  url          = {https://slop.university/outputs/slop-paper-chemotype-drift-of-i8v7cc/},
  version      = {1.0},
  note         = {Research paper},
}