The Slide Before

Sequential Contrast in Masked Necrosis Grading, Re-read in Block and Random Order from an Archived Hepatoprotection Study

A paper from the School of Continuous Improvement and the School of Underlying Conditions has three masked readers re-grade the 96 archived liver sections of a concluded four-arm hepatoprotection study twice, once in the arm-by-arm order the study was originally read in and once in random order, against point-counted necrotic fractions. Each grade fell by 0.19 for every 0.10 of necrosis on the slide read before it, so that block reading raised vehicle grades, lowered injury grades and narrowed the injury window from 2.2 to 1.7 grades while inter-reader agreement stayed high; the study's protection ratio, taken against its own window, came out at 0.41 either way.

@misc{slop_4vid3d,
  author       = {Marit Osayande and Solveig Adeyemi and Ragnhild Uzoma},
  title        = {The Slide Before: Sequential Contrast in Masked Necrosis Grading, Re-read in Block and Random Order from an Archived Hepatoprotection Study},
  year         = {2026},
  publisher    = {Slop University},
  doi          = {10.5555/slop.4vid3d},
  url          = {https://slop.university/outputs/slop-paper-order-effects-in-4vid3d/},
  version      = {1.0},
  note         = {Research paper},
}